Office of Research - Mentors

Training Grant

• James Baker, Jr.    jbakerjr@med.umich.edu
  Nanotechnology, autoimmunity and biotechnology
  http://www2.med.umich.edu/departments/internalmedicine/index.cfm?fuseaction=intmed.facultyBio&individual_id=35475
  
  
• Kate Barald    kfbarald@umich.edu
  Developmental neurobiology, molecular neurobiology studies of developing neuronal cell and synapses; gene expression in the neural crest. This laboratory works on four different developmental problems. We are interested in the early development of neuronal lineages from the embryonic neural crest; which appears transiently during development and which is a source of peripheral nervous system neurons, among many other cell types. We use specific monoclonal antibodies and no-flow cytometry to isolate neural crest subpopulations. We also study the role of the neurofibromatosis I gene (a tumor suppressor gene) in neural crest development and neuronal/ melanocyte/Schwann cell lineage specification and apoptosis, using mouse embryonic stem cells. An additional line of research examines the role of the embryonic hindbrain, periotic mesenchyme and neural crest in shaping inner ear development and the roles of transcription factor and growth factor genes (e.g. BMPs) and their antagonists, such as Noggin, Chordin and DAN, in axis formation and development of the embryonic otocyst. We examine these issues in four model systems:, chick/quail; mouse/ immortalized inner ear cell lines from the Immortomouse and the zebrafish.
  http://www.med.umich.edu/cdb/sub_pages/People/barald.htm
  
  
• Mark Burns    maburns@umich.edu
  Biochemical separations, field-enhanced separations, microfabricated chemical analysis systems, DNA genotyping and sequencing
  http://www.engin.umich.edu/dept/cheme/people/burns.html
  
  
• Sally Camper    scamper@umich.edu
  Development and function of the neuroendocrine and auditory system using transgenic mice, gene targeting, and molecular genetic analysis of mouse and human mutations.
  http://www.hg.med.umich.edu/labs/camper/index.html
  
  
• Daniel Jr. Chiego    djchiego@umich.edu
  role of nerves in maintenance and repair of mineralized tissues; neural control of salivation
  http://www.dent.umich.edu/crse/staff/chiegojrdaniel
  
  
• James Engle    engle@umich.edu
  Mammalian Developmental Genetics: We employ molecular genetics to investigate the basic mechanisms underlying developmental determination during mammalian embryogenesis.
  http://www.med.umich.edu/cdb/sub_pages/People/engel.htm
  
  
• Renny Franceschi    rennyf@umich.edu
  signals regulating differentiation and function of osteoblasts, and gene therapy approaches for bone regeneration
  http://www.dent.umich.edu/research/ccr/rennyf.htm
  
  
• William Giannobile    wgiannob@umich.edu
  gene delivery strategies for oral and periodontal tissue engineering, signal transduction mechanisms during oral wound repair, and clinical trials relevant to oral microfluidic diagnostics
  http://www.dent.umich.edu/pom/research/labs/giannobile
  
  
• Steven Goldstein    stevegld@umich.edu
  His research is focused on studying mechanical and biologic stimuli of bone formation, regeneration and adaptation. Using a hierarchical approach, the laboratory tests hypotheses across multiple scales, ranging from signaling pathways associated with mechanotransduction to biomechanical material property characterizations.
  http://www.iog.umich.edu/faculty/goldstein.html
  
  
• Deborah Gumucio    dgumucio@umich.edu
  Regulation of globin genes in transgenic mice. Potential to impact the treatment of Sickle Cell anemia and betat thalassemia. Moleculat factors that control development of the intestine. Factors that regulate this program may be the same factors that are involved in the development of intestinal metaplasias in stomach and esophagus. Metaplasias are precursors to cancer.
  http://www.med.umich.edu/cdb/sub_pages/People/gumucio.htm
  
  
• Peter Hitchcock    peterh@umich.edu
  Research in my lab is focused on the cellular and molecular biology of brain development, injury and regeneration. Currently two lines of research are being explored. The first is injury-induced neuronal regeneration in teleost fish; the second is ocular morphogenesis in mammals.
  http://www.med.umich.edu/cdb/sub_pages/People/hitchcock.htm
  
  
• Scott Hollister    scottho@umich.edu
  Biomaterial scaffold design, tissue engineering, image-based engineering, computational modeling of tissues.
  http://www.dent.umich.edu/research/ccr/hollister.htm
  
  
• Alan Hunt    ajhunt@umich.edu
  Among the most fundamental processes of life is the ability to move, at the cellular level these forces are generated by proteins known as molecular moters. Two broad classes of molecular motors: 1) those that use energy derived from ATP to exert force against filaments such as myosin, kinesin, and dynein, and 2) those that use energy stored in an electrochemical gradient across a membrane to dirve rotational movements, such as the motors that direve bacterial flagella.
  http://www.umich.edu/~huntlab/
  
  
• Sunil Kapila    skapila@umich.edu
  molecular, cellular and in vivo mechanisms of hormonal modulation of cartilage degradation; bioengineering of heterogenous fibrocartilaginous tissues using mechano-biologic stimulation of mesenchymal stem cells; periodontal osteolysis mediated by matrix metalloproteinases
  http://www.dent.umich.edu/opd/graduateprograms/ortho/faculty/kapila
  
  
• Yvonne Kapila    ykapila@umich.edu
  extracellular matrix regulation of periodontal pathogenesis and oral cancer; apoptosis signaling
  http://www.dent.umich.edu/pom/research/labs/yklab